Endometriosis Trials

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EPiC

EPiC is a single-arm open label exploratory clinical trial to evaluate Dichloroacetate (DCA) as a possible treatment for endometriosis-associated pain.

Why?

To test the hypothesis that we have developed effective methods to study DCA as a potential oral treatment to alleviate pain in women with endometriosis.

 

Who?

Pre-menopausal women aged 18 or over-diagnosed with superficial peritoneal endometriosis (Stage I or II) at laparoscopy (>2 weeks but <5 years ago) who are using/willing to use effective contraception if necessary.

 

Where?

NHS Lothian

 

Recruitment target

30 women

https://www.ed.ac.uk/centre-reproductive-health/exppect

endometriosis/research/epic   

 

Contact: Priscilla.Fernandez@nhslothian.scot.nhs.uk

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ESPriT 1

ESPriT is a randomised controlled feasibility trial evaluating the effectiveness of laparoscopic treatment of isolated Superficial Peritoneal endometriosis for managing chronic pelvic pain in women.

Why?

To inform the design of and assess the feasibility of a future definitive trial to determine whether surgical treatment of superficial peritoneal endometriosis improves overall symptoms and quality of life more than not surgically treating the endometriosis, or whether surgery could exacerbate symptoms, or even cause harm.

 

Who?

Women who are undergoing laparoscopy to determine whether pelvic pain is due to endometriosis.

 

Where?

Multi centre across Scotland

 

Recruitment target

90 women 

https://www.ed.ac.uk/centre-reproductive-health/exppect-endometriosis/research/esprit

 

Contact: Nicola.Watson@nhslothian.scot.nhs.uk

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A tissue resource used in laboratory-based studies to improve understanding of endometriosis and identify potential therapeutic targets.

Why?

To identify genes and gene pathways responsible for the development of endometriotic lesions, endometriosis-associated pain and identify gene targets for therapeutic intervention.

Who?

Women who are scheduled for pelvic surgery for benign gynaecological conditions.

Where?

Royal Infirmary of Edinburgh and St John’s Hospital, Livingston.

Recruitment target

400 women across both sites.

 

 

Contact: Ashleigh.Symington@nhslothian.scot.nhs.uk